Herbal extracts including Centella support equine skin
View study ↗In equine skin models, herbal extracts including Centella asiatica showed soothing and regenerative effects that supported healthy skin.
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Independent source library
The Research Behind Gray-Out
Research behind the skin-conditioning and pigment-supporting botanicals in Gray-Out.
Gray-Out is a topical formula built around botanicals and skin-active compounds selected for their antioxidant, pigment-supporting, and skin-soothing properties. Every source below is an independent, peer-reviewed publication, grouped by ingredient — with horse research featured first.
Horse study = research conducted in horses
Centella asiatica (Gotu Kola)A skin-conditioning botanical studied in horses for skin support.
Centella asiatica is one of the best-documented skin-support botanicals, with equine research plus a strong human dermatology record.
Centella asiatica for skin health (review)
View study ↗This review documents Centella's ability to boost collagen, strengthen the skin barrier, and soothe the skin, supporting its wide use in skin-care formulas.
Frankincense (Boswellia)A resin traditionally applied to soothe and support the skin.
Topical boswellic acids have controlled human studies supporting their soothing, antioxidant effects on the skin.
Topical boswellic acids improve skin quality
View study ↗A topical boswellic-acid cream measurably improved skin texture, elasticity, and appearance in a controlled split-side comparison.
Boswellia extract for photo-damaged skin
View study ↗Boswellia-based topical treatment improved the appearance of sun-damaged skin, supporting its soothing and protective role in topical formulas.
Turmeric (Curcumin)A topical antioxidant that soothes the skin.
Curcumin applied to the skin has clinical and review evidence for antioxidant and soothing benefits.
Curcumin in dermatology (review)
View study ↗This review summarizes curcumin's antioxidant and soothing effects on the skin and its documented benefits across a range of skin concerns.
Topical curcumin improves skin condition (clinical study)
View study ↗A topical curcumin formulation improved measurable skin parameters, reinforcing its role as a soothing, antioxidant skin ingredient.
Green Tea (EGCG)A potent antioxidant that helps protect skin from oxidative stress.
Green tea polyphenols, especially EGCG, are well documented for protecting skin cells against oxidative and UV-related damage.
Green tea polyphenols protect the skin
View study ↗Green tea polyphenols protected skin against oxidative stress and UV-related damage, supporting EGCG's use as a topical antioxidant.
Nicotinamide (Vitamin B3)A skin-barrier vitamin studied for pigment support and skin protection.
Nicotinamide has strong clinical evidence as a topical skin ingredient, including skin-barrier and pigment-focused studies.
Niacinamide reduces excess skin pigmentation
View study ↗Topical niacinamide significantly reduced the transfer of pigment to skin cells, visibly evening areas of excess pigmentation.
Tranexamic AcidA topical compound studied for evening out skin pigmentation.
Tranexamic acid has become a well-studied topical ingredient for supporting even, balanced skin pigmentation.
Topical tranexamic acid for uneven pigmentation
View study ↗Topical tranexamic acid significantly reduced areas of excess pigmentation, supporting its use for more even skin tone.
BakuchiolA gentle, plant-derived retinol alternative for skin renewal.
Bakuchiol is a plant-derived compound shown to deliver retinol-like skin benefits with better tolerability.
Bakuchiol performs comparably to retinol (clinical trial)
View study ↗Bakuchiol matched retinol for improving skin appearance and texture, but caused less dryness and irritation, making it a gentle skin-renewal ingredient.