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The Research Behind Equi-Gut+

Peer-reviewed research supporting Saccharomyces boulardii, aloe vera, marshmallow, ginger, and beta-glucan — with horse studies featured first.

Equi-Gut+ pairs soothing botanicals with a well-studied equine probiotic yeast to support a healthy stomach lining, balanced hindgut, and comfortable digestion. Every source below is an independent, peer-reviewed publication, grouped by ingredient — with horse studies featured first.

Horse study = research conducted in horses

Saccharomyces boulardiiA probiotic yeast studied directly in horses for digestive balance.

This probiotic yeast has some of the strongest equine evidence of any gut-support ingredient, with multiple horse studies and controlled trials.

S. boulardii and digestive recovery in horses (clinical trial)

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Horse studyRandomized clinical trial

In hospitalized horses recovering from digestive upset, Saccharomyces boulardii supported a faster return to normal manure compared with placebo.

Probiotic yeast supports foals during antibiotic treatment

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Horse studyControlled trial

Foals receiving S. boulardii showed improved stool consistency and fewer days of abnormal manure while on antibiotics, supporting its role in the gut.

Probiotics and the equine gut microbiota (review)

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Equine reviewHorses

This equine-focused review summarizes how probiotic supplementation, including S. boulardii, can help stabilize the horse's gut microbiota during stress and disruption.

Aloe VeraA mucilaginous gel studied in horses for soothing the stomach lining.

Aloe vera has been tested directly in horses for stomach-lining health, with additional supportive evidence for the stomach lining.

Aloe vera and stomach-lining health in horses (clinical trial)

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Horse studyClinical trial

In horses evaluated for stomach-lining health, aloe vera gel supported improved stomach-lining scores under veterinary evaluation.

Aloe vera supports the stomach lining

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Controlled in vivo studyRats

Aloe vera gel supported the stomach lining, boosting protective mucus and growth factors while supporting a normal inflammatory response in the gastric lining.

Marshmallow RootA demulcent herb that forms a soothing coating over irritated tissue.

Marshmallow root is rich in soothing mucilage that coats and protects the digestive lining, with published evidence for supporting the gastric lining.

Marshmallow root supports the gastric lining

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Controlled in vivo studyAnimals

Marshmallow root extract supported the gastric lining and reduced stomach-lining irritation, supporting its traditional use as a soothing digestive herb.

Marshmallow mucilage soothes and coats irritated tissue

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Laboratory studyCell/tissue model

Marshmallow polysaccharides adhered to and protected the cells lining the digestive and respiratory tracts, and supported irritated tissue.

GingerA warming root with well-documented antioxidant and gut-soothing effects.

Ginger is one of the best-studied digestive botanicals, with published evidence for supporting the stomach and a normal inflammatory response in the gut.

Ginger supports the stomach lining

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Controlled in vivo studyAnimals

Ginger extract supported the stomach lining against irritation, largely through its potent antioxidant activity.

Ginger's antioxidant and digestive actions (review)

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Peer-reviewed reviewMulti-species

This review documents ginger's antioxidant and gut-motility-supporting effects that underpin its traditional use for digestive comfort.

Beta-GlucanA natural fiber that supports gut immunity and a balanced microbiome.

Beta-glucans are prebiotic fibers that nourish beneficial gut bacteria and support the gut's immune barrier, with supportive evidence in animals and people.

Dietary beta-glucan supports gut health in animals

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Controlled feeding trialAnimals

Feeding beta-glucan improved gut-barrier and immune markers, supporting its role as a prebiotic that helps maintain a healthy, resilient digestive tract.

Beta-glucan, the microbiome, and gut immunity (review)

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Peer-reviewed reviewMulti-species

This review summarizes how beta-glucan acts as a prebiotic and immune modulator, feeding beneficial bacteria and strengthening the gut's natural defenses.